Your BLADDR case challenge
Guillaume, a 55-years-old master chef in a famous 3-star restaurant, never tastes the food he prepares "because it goes straight to his hips", yet secretly stops by a highway hamburger restaurant on his way home for a big hamburger with French fries and a milkshake.
He is diagnosed with metastatic bladder cancer during a work up for dysuria.
Assessment summary:
- Medical history: diabetes mellitus and diabetic nephropathy, otherwise healthy
- CT chest, abdomen, pelvis: diffuse liver and lung metastases
- ECOG PS: 0
- Peripheral neuropathy: grade I due to diabetes mellitus
- No hearing impairment, COPD or heart failure
- Glomerular filtration rate (GFR): 40 ml/min due to diabetic nephropathy
- PD-L1 expression: strongly positive, based on Agilent assay with CPS 50